H2O2, a Necessary Evil for Cell Signaling

@article{Rhee2006H2O2AN,
  title={H2O2, a Necessary Evil for Cell Signaling},
  author={Sue Goo Rhee},
  journal={Science},
  year={2006},
  volume={312},
  pages={1882 - 1883}
}
  • S. Rhee
  • Published 30 June 2006
  • Biology
  • Science
Once considered lethal to cells, reactive oxygen species are now known to be involved in redox signaling pathways that may contribute to normal cell function as well as disease progression. 
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It is found that Nox2-derived ROS influence the formation of an active interleukin-1 (IL-1) receptor complex in the endosomal compartment by directing the H2O2-dependent binding of TRAF6 to the IL-1R1/MyD88 complex.
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Intracellular Reactive Oxygen Species Activate Src Tyrosine Kinase during Cell Adhesion and Anchorage-Dependent Cell Growth
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Results suggest that Cdc2-mediated phosphorylation and inactivation of Prx I and the resulting intracellular accumulation of H2O2 might be important for progression of the cell cycle.