H2O2, a Necessary Evil for Cell Signaling

  title={H2O2, a Necessary Evil for Cell Signaling},
  author={Sue Goo Rhee},
  pages={1882 - 1883}
  • S. Rhee
  • Published 30 June 2006
  • Biology
  • Science
Once considered lethal to cells, reactive oxygen species are now known to be involved in redox signaling pathways that may contribute to normal cell function as well as disease progression. 
Peroxiredoxin-2 links Cdk5 to neurodegeneration
Cyclin-dependent kinase 5, a serine/threonine kinase, contributes to neurodegeneration in Parkinson's disease. This kinase is now shown to phosphorylate peroxiredoxin-2, inactivating it, and thereby
Chemokine-dependent T cell migration requires aquaporin-3–mediated hydrogen peroxide uptake
The water/glycerol channel aquaporin-3 is required for chemokine-dependent T cell migration during immune responses.
Control of the pericentrosomal H2O2 level by peroxiredoxin I is critical for mitotic progression
Reversible oxidative inactivation of centrosome-bound protein phosphatases such as Cdc14B by H2O2 is likely responsible for the inhibition of Cdk1-opposing phosphatases during early mitosis, which
Revealing the signaling regulation of hydrogen peroxide to cell pyroptosis using a ratiometric fluorescent probe in living cells.
The results reported here demonstrate that H2O2, as a principal member of ROS, is a critical upstream signaling molecule in regulating pyroptosis.
Myeloperoxidase-derived oxidants: their Intracellular targets, defence mechanisms and role in disease
ix List of Figures xii List of Schemes xv List of Tables xvi List of Abbreviations xvii Publications arising from this Thesis xxii CHAPTER
Defining the molecular basis of H2S-mediated sensing and signalling
The Blood Pressure-Lowering Action of the Reductant Hydrogen Sulfide Is Paradoxically Mediated by the Oxidative Activation of Protein Kinase G.
Iron uptake controls the generation of Leishmania infective forms through regulation of ROS levels
Iron uptake promotes hydrogen peroxide–dependent differentiation of Leishmania promastigote into infective amastigotes into infectives amastsigotes.


NOX enzymes and the biology of reactive oxygen
Professional phagocytes generate high levels of reactive oxygen species (ROS) using a superoxide-generating NADPH oxidase as part of their armoury of microbicidal mechanisms, leading to the concept that ROS are 'intentionally' generated in these cells with distinctive cellular functions related to innate immunity, signal transduction and modification of the extracellular matrix.
Nox2 and Rac1 Regulate H2O2-Dependent Recruitment of TRAF6 to Endosomal Interleukin-1 Receptor Complexes
It is found that Nox2-derived ROS influence the formation of an active interleukin-1 (IL-1) receptor complex in the endosomal compartment by directing the H2O2-dependent binding of TRAF6 to the IL-1R1/MyD88 complex.
The phagocyte NADPH oxidase depends on cholesterol‐enriched membrane microdomains for assembly
It is shown that insolubility of NADPH oxidase subunits in nonionic detergents TX‐100, Brij‐58, and Brij-98 is a consequence of inclusion into cholesterol‐enriched membrane microdomains (lipid rafts).
Subcellular targeting of oxidants during endothelial cell migration
It is found that the nicotinamide adenine dinucleotide phosphate reduced (NADPH) oxidase adaptor p47phox and its binding partner TRAF4 were sequestered within nascent, focal complexlike structures in the lamellae of motile endothelial cells.
Intracellular Reactive Oxygen Species Activate Src Tyrosine Kinase during Cell Adhesion and Anchorage-Dependent Cell Growth
The results suggest that reactive oxygen species are key mediators of in vitro and in vivo v-Src tumorigenic properties, as both antioxidant treatments and the oxidant-insensitive C245A and C487A Src mutants greatly decrease invasivity, serum-independent and anchorage-independent growth, and tumor onset.
Regulation of Peroxiredoxin I Activity by Cdc2-mediated Phosphorylation*
Results suggest that Cdc2-mediated phosphorylation and inactivation of Prx I and the resulting intracellular accumulation of H2O2 might be important for progression of the cell cycle.