H2B ubiquitylation is part of chromatin architecture that marks exon-intron structure in budding yeast

@inproceedings{Shieh2011H2BUI,
  title={H2B ubiquitylation is part of chromatin architecture that marks exon-intron structure in budding yeast},
  author={Grace S. Shieh and Chin-Hua Pan and Jia-Hong Wu and Yun-Ju Sun and Chia-Chang Wang and Wei-Chun Hsiao and Chia-Yeh Lin and Luh Tung and Tien-Hsien Chang and Alastair B Fleming and Cory Hillyer and Yi-Chen Lo and Shelley L Berger and Mary Ann Osley and Cheng-Fu Kao},
  booktitle={BMC Genomics},
  year={2011}
}
The packaging of DNA into chromatin regulates transcription from initiation through 3' end processing. One aspect of transcription in which chromatin plays a poorly understood role is the co-transcriptional splicing of pre-mRNA. Here we provide evidence that H2B monoubiquitylation (H2BK123ub1) marks introns in Saccharomyces cerevisiae. A genome-wide map of H2BK123ub1 in this organism reveals that this modification is enriched in coding regions and that its levels peak at the transcribed regions… CONTINUE READING
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