H2AZ Is Enriched at Polycomb Complex Target Genes in ES Cells and Is Necessary for Lineage Commitment

@article{Creyghton2008H2AZIE,
  title={H2AZ Is Enriched at Polycomb Complex Target Genes in ES Cells and Is Necessary for Lineage Commitment},
  author={Menno P. Creyghton and Styliani Markoulaki and Stuart S. Levine and Jacob Hanna and Michael A Lodato and Ky Sha and Richard A. Young and Rudolf Jaenisch and Laurie A. Boyer},
  journal={Cell},
  year={2008},
  volume={135},
  pages={649-661}
}
Elucidating how chromatin influences gene expression patterns and ultimately cell fate is fundamental to understanding development and disease. The histone variant H2AZ has emerged as a key regulator of chromatin function and plays an essential but unknown role during mammalian development. Here, genome-wide analysis reveals that H2AZ occupies the promoters of developmentally important genes in a manner that is remarkably similar to that of the Polycomb group (PcG) protein Suz12. By using RNAi… CONTINUE READING
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Preferential occupancy of histone variant H2AZ at inactive promoters influences local histone modifications and chromatin remodeling.

Proceedings of the National Academy of Sciences of the United States of America • 2005
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