H2AX Phosphorylation: Its Role in DNA Damage Response and Cancer Therapy

  title={H2AX Phosphorylation: Its Role in DNA Damage  Response and Cancer Therapy},
  author={Monika Podhorecka and Andrzej C. Skladanowski and Przemyslaw M Bozko},
  booktitle={Journal of nucleic acids},
Double-strand breaks (DSBs) are the most deleterious DNA lesions, which, if left unrepaired, may have severe consequences for cell survival, as they lead to chromosome aberrations, genomic instability, or cell death. Various physical, chemical, and biological factors are involved in DSB induction. Cells respond to DNA damage by activating the so-called DNA damage response (DDR), a complex molecular mechanism developed to detect and repair DNA damage. The formation of DSBs triggers activation of… CONTINUE READING


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