H2 receptor mediated inhibition of immediate type hypersensitivity reactions in vivo.

@article{Drazen1978H2RM,
  title={H2 receptor mediated inhibition of immediate type hypersensitivity reactions in vivo.},
  author={Jeffrey M Drazen and C. S. Venugopalan and Nicholas A. Soter},
  journal={The American review of respiratory disease},
  year={1978},
  volume={117 3},
  pages={479-84}
}
The effects of H2-blocking agents and the H2 receptor agonist, 4-methylhistamine, on the severity of anaphylactic reactions were studied in the guinea pig in vivo. The increase in gas volume of the lungs 90 sec after intravenous infusion of ovalbumin in animals immunized previously by intraperitoneal ovalbumin injection was used as an index of the severity of the reaction in vivo. The H2 receptor antagonists burimamide (1.0 and 3.0 mg per kg) and metiamide (3 mg per kg) significantly increased… CONTINUE READING