H2-M3–restricted CD8+ T cells are not required for MHC class Ib–restricted immunity against Listeria monocytogenes

@article{DOrazio2006H2M3restrictedCT,
  title={H2-M3–restricted CD8+ T cells are not required for MHC class Ib–restricted immunity against Listeria monocytogenes},
  author={Sarah E F D'Orazio and Christine A. Shaw and Michael N. Starnbach},
  journal={The Journal of Experimental Medicine},
  year={2006},
  volume={203},
  pages={383 - 391}
}
Studies using major histocompatibility complex (MHC)-Ia-deficient mice have shown that MHC-Ib-restricted CD8+ T cells can clear infections caused by intracellular pathogens such as Listeria monocytogenes. M3-restricted CD8+ T cells, which recognize short hydrophobic N-formylated peptides, appear to comprise a substantial portion of the MHC-Ib-restricted T cell response in the mouse model of L. monocytogenes infection. In this study, we isolated formyltransferase (fmt) mutant strains of L… CONTINUE READING

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