H19 and Igf2 monoallelic expression is regulated in two distinct ways by a shared cis acting regulatory region upstream of H19.

@article{Srivastava2000H19AI,
  title={H19 and Igf2 monoallelic expression is regulated in two distinct ways by a shared cis acting regulatory region upstream of H19.},
  author={Madhulika Srivastava and S. T. Hsieh and Alex Grinberg and Lisa Williams-Simons and Sing Ping Huang and Karl Pfeifer},
  journal={Genes & development},
  year={2000},
  volume={14 10},
  pages={1186-95}
}
H19 and Igf2 are expressed in a monoallelic fashion from the maternal and paternal chromosomes, respectively. A region upstream of H19 has been shown to regulate such imprinted expression of both genes in cis. We have taken advantage of a loxP/cre recombinase-based strategy to delete this region in mice in a conditional manner to determine the temporal requirement of the upstream region in initiating and maintaining the imprinted expression of H19 and Igf2. Analysis of allele-specific… CONTINUE READING
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