H19 and Igf2 monoallelic expression is regulated in two distinct ways by a shared cis acting regulatory region upstream of H19.

@article{Srivastava2000H19AI,
  title={H19 and Igf2 monoallelic expression is regulated in two distinct ways by a shared cis acting regulatory region upstream of H19.},
  author={M. Srivastava and S. Hsieh and A. Grinberg and L. Williams-Simons and S. Huang and K. Pfeifer},
  journal={Genes & development},
  year={2000},
  volume={14 10},
  pages={
          1186-95
        }
}
  • M. Srivastava, S. Hsieh, +3 authors K. Pfeifer
  • Published 2000
  • Biology, Medicine
  • Genes & development
  • H19 and Igf2 are expressed in a monoallelic fashion from the maternal and paternal chromosomes, respectively. A region upstream of H19 has been shown to regulate such imprinted expression of both genes in cis. We have taken advantage of a loxP/cre recombinase-based strategy to delete this region in mice in a conditional manner to determine the temporal requirement of the upstream region in initiating and maintaining the imprinted expression of H19 and Igf2. Analysis of allele-specific… CONTINUE READING
    141 Citations
    A transcriptional insulator at the imprinted H19/Igf2 locus.
    • 152
    • PDF
    Regulatory Mechanisms at the MouseIgf2/H19 Locus
    • 87
    • PDF
    Deletion of a silencer element disrupts H19 imprinting independently of a DNA methylation epigenetic switch.
    • 97
    • PDF
    Deletion of a direct repeat element has no effect on Igf2 and H19 imprinting
    • 30
    H19ICR mediated transcriptional silencing does not require target promoter methylation.
    • 3
    CTCF maintains differential methylation at the Igf2/H19 locus
    • 325
    • PDF
    The H19 gene: regulation and function of a non-coding RNA
    • 188

    References

    SHOWING 1-10 OF 43 REFERENCES
    An enhancer deletion affects both H19 and Igf2 expression.
    • 403
    • PDF
    Chromatin conformation of the H19 epigenetic mark.
    • 89
    • PDF
    A silencer element identified in Drosophila is required for imprinting of H19 reporter transgenes in mice.
    • 51
    • PDF
    The structural H19 gene is required for transgene imprinting.
    • 96
    • PDF
    Enhancer competition between H19 and Igf2 does not mediate their imprinting.
    • 105
    • PDF