• DOI:10.1101/GAD.14.10.1186
Corpus ID: 41475543

H19 and Igf2 monoallelic expression is regulated in two distinct ways by a shared cis acting regulatory region upstream of H19.

@article{Srivastava2000H19AI,
  title={H19 and Igf2 monoallelic expression is regulated in two distinct ways by a shared cis acting regulatory region upstream of H19.},
  author={M. Srivastava and S. Hsieh and A. Grinberg and L. Williams-Simons and S. Huang and K. Pfeifer},
  journal={Genes & development},
  year={2000},
  volume={14 10},
  pages={
          1186-95
        }
}

M. Srivastava, S. Hsieh, +3 authors K. Pfeifer

Published 2000

Biology, Medicine

Genes & development

H19 and Igf2 are expressed in a monoallelic fashion from the maternal and paternal chromosomes, respectively. A region upstream of H19 has been shown to regulate such imprinted expression of both genes in cis. We have taken advantage of a loxP/cre recombinase-based strategy to delete this region in mice in a conditional manner to determine the temporal requirement of the upstream region in initiating and maintaining the imprinted expression of H19 and Igf2. Analysis of allele-specific… CONTINUE READING

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