H11 kinase is a novel mediator of myocardial hypertrophy in vivo.

@article{Depr2002H11KI,
  title={H11 kinase is a novel mediator of myocardial hypertrophy in vivo.},
  author={Christophe Depr{\'e} and Makoto Hase and Vinciane Gaussin and Anna Zając and Li Wang and Luc Hittinger and Bijan Ghaleh and Xianzhong Yu and Raymond K. Kudej and Thomas Wagner and Junichi Sadoshima and Stephen F. Vatner},
  journal={Circulation research},
  year={2002},
  volume={91 11},
  pages={1007-14}
}
By subtractive hybridization, we found a significant increase in H11 kinase transcript in large mammalian models of both ischemia/reperfusion (stunning) and chronic pressure overload with hypertrophy. Because this gene has not been characterized in the heart, the goal of the present study was to determine the function of H11 kinase in cardiac tissue, both in vitro and in vivo. In isolated neonatal rat cardiac myocytes, adenoviral-mediated overexpression of H11 kinase resulted in a 37% increase… CONTINUE READING