H1-receptor antagonists. Comparative tolerability and safety.

  title={H1-receptor antagonists. Comparative tolerability and safety.},
  author={F. Estelle R. Simons},
  journal={Drug safety},
  volume={10 5},
First-generation histamine H1-receptor antagonists, such as diphenhydramine, triprolidine, hydroxyzine or chlorpheniramine (chlorphenamine), frequently cause somnolence or other CNS adverse effects. Second-generation H1-antagonists, such as terfenadine, astemizole, loratadine and cetirizine, represent a true advance in therapeutics. In manufacturers' recommended doses, they have a more favourable benefit/risk ratio than their predecessors with regard to lack of CNS effects, and do not… CONTINUE READING