H1-receptor antagonists: safety issues.

@article{Estelle1999H1receptorAS,
  title={H1-receptor antagonists: safety issues.},
  author={F. Estelle and Robert A. Simons},
  journal={Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology},
  year={1999},
  volume={83 5},
  pages={481-8}
}
Histamine is an important neurotransmitter. Old (first-generation) H1-receptor antagonists such as chlorpheniramine, diphenhydramine, or triprolidine produce histamine blockade at H1-receptors in the central nervous system (CNS) and frequently cause somnolence or other CNS adverse effects. New (second generation) H1-antagonists such as cetirizine, fexofenadine, and loratadine represent an advance in therapeutics; in manufacturers' recommended doses, they enter the CNS in smaller amounts… CONTINUE READING
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