H1- and H2-histamine receptor blockers and opiate analgesia in mice.

@article{Leza1990H1AH,
  title={H1- and H2-histamine receptor blockers and opiate analgesia in mice.},
  author={Juan Carlos Leza and Ignacio Lizasoain and Ph. Lorenzo},
  journal={Methods and findings in experimental and clinical pharmacology},
  year={1990},
  volume={12 10},
  pages={
          671-8
        }
}
In this paper, the interactions between opiates and antihistaminic compounds, both H1- and H2-blockers, were studied. CD1 mice were used, treated with saline, morphine CHl (5 mg/kg), and 1 or 10 mg/kg of the H1-antihistaminics tripelennamine, chlorpheniramine, diphenhydramine and cyclizine and the H2-antihistaminics ranitidine and cimetidine, all compounds by s.c. route. Using the hot-plate test, it was observed that the two doses of tripelennamine and the higher doses of chlorpheniramine and… CONTINUE READING

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