H1 RNA polymerase III promoter-driven expression of an RNA aptamer leads to high-level inhibition of intracellular protein activity

@article{Mi2006H1RP,
  title={H1 RNA polymerase III promoter-driven expression of an RNA aptamer leads to high-level inhibition of intracellular protein activity},
  author={Jing Mi and Xiuwu Zhang and Zahid N. Rabbani and Yingmiao Liu and Zhen Su and Zeljko Vujaskovi{\'c} and Christopher D. Kontos and Bruce A. Sullenger and Bryan M. Clary},
  journal={Nucleic Acids Research},
  year={2006},
  volume={34},
  pages={3577 - 3584}
}
Aptamers offer advantages over other oligonucleotide-based approaches that artificially interfere with target gene function due to their ability to bind protein products of these genes with high affinity and specificity. However, RNA aptamers are limited in their ability to target intracellular proteins since even nuclease-resistant aptamers do not efficiently enter the intracellular compartments. Moreover, attempts at expressing RNA aptamers within mammalian cells through vector-based… CONTINUE READING

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