H1 Antihistamines: Current Status and Future Directions

  title={H1 Antihistamines: Current Status and Future Directions},
  author={Francesca E. Simon and Keith J. Simons},
  booktitle={The World Allergy Organization journal},
In this review, we compare and contrast the clinical pharmacology, efficacy, and safety of first-generation H1 antihistamines and second-generation H1 antihistamines. First-generation H1 antihistamines cross the blood-brain barrier, and in usual doses, they potentially cause sedation and impair cognitive function and psychomotor performance. These medications, some of which have been in use for more than 6 decades, have never been optimally investigated. Second-generation H1 antihistamines such… CONTINUE READING
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