H1‐antihistamines: inverse agonism, anti‐inflammatory actions and cardiac effects

@article{Leurs2002H1antihistaminesIA,
  title={H1‐antihistamines: inverse agonism, anti‐inflammatory actions and cardiac effects},
  author={Rob Leurs and M. K. Church and Maurizio Taglialatela},
  journal={Clinical \& Experimental Allergy},
  year={2002},
  volume={32}
}
This review addresses novel concepts of histamine H1‐receptor function and attempts to relate them to the anti‐inflammatory effects of H1‐antihistamines. Furthermore, the molecular mechanisms underlying the cardiotoxic effects of H1‐antihistamines are discussed. 

Advances in H1-antihistamines.

  • F. Simons
  • Medicine, Biology
    The New England journal of medicine
  • 2004
TLDR
There are clinically relevant differences among H1-antihistamines in their pharmacology and safety profiles in allergic rhinoconjunctivitis and chronic urticaria.

Cetirizine, an H1‐receptor antagonist, suppresses the expression of macrophage migration inhibitory factor: its potential anti‐inflammatory action

TLDR
Cetirizine, a putative H1‐receptor antagonist, has recently been shown to have anti‐inflammatory properties through the inhibition of leucocyte recruitment and activation, and by the reduction of ICAM‐1 expression on keratinocytes.

Inverse agonists of H1-receptors as promising antiallergy agents (a review)

  • I. Gushchin
  • Biology, Medicine
    Pharmaceutical Chemistry Journal
  • 2010
TLDR
The broadening of clinical indications for the administration of inverse agonists of H1-receptors aimed at preventing the exacerbation of allergic (atopic) disorders and inhibiting allergic inflammation processes is justified.

Antihistamines and their role as antipruritics

TLDR
H1 antihistamines have proven to be effective at reversing the pruritus and cutaneous lesions of chronic urticaria, but their ability to treatPruritus associated with other cutaneous and systemic diseases is unproven.

Anti‐inflammatory properties of antihistamines: an update

TLDR
It is suggested that prophylactic/long-term treatment with cetirizine and levocetirIZine may provide an opportunity to prevent/delay the development of asthma in susceptible individuals and to improve the QOL in patients with persistent AR.

H 1 ANTIHISTAMINES IN ALLERGIC DISEASE

TLDR
Second-generation antihistamines are preferred to their predecessors because of better benefit-to-risk ratios, and are not only more potent, but also have anti-allergic and antiinflammatory properties.

New oral H1 antihistamines in children: facts and unmeet needs

Background:  Second‐generation antihistamines differ from first‐generation ones because of their elevated specificity and affinity for peripheral H1‐receptors and because of their lower penetration

Antihistamines in pediatric allergy

TLDR
This review will highlight the characteristics of H1 antihistamines and their indications in pediatric allergic disorders.

Comparative pharmacology of H1 antihistamines: clinical relevance.

  • F. Simons
  • Medicine, Biology
    The American journal of medicine
  • 2002
...

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