H1‐antihistamines: inverse agonism, anti‐inflammatory actions and cardiac effects

@article{Leurs2002H1antihistaminesIA,
  title={H1‐antihistamines: inverse agonism, anti‐inflammatory actions and cardiac effects},
  author={Rob Leurs and Martin K. Church and Maurizio Taglialatela},
  journal={Clinical \& Experimental Allergy},
  year={2002},
  volume={32}
}
This review addresses novel concepts of histamine H1‐receptor function and attempts to relate them to the anti‐inflammatory effects of H1‐antihistamines. Furthermore, the molecular mechanisms underlying the cardiotoxic effects of H1‐antihistamines are discussed. 
Advances in H1-antihistamines.
  • F. Simons
  • Medicine
  • The New England journal of medicine
  • 2004
TLDR
There are clinically relevant differences among H1-antihistamines in their pharmacology and safety profiles in allergic rhinoconjunctivitis and chronic urticaria. Expand
Cetirizine, an H1‐receptor antagonist, suppresses the expression of macrophage migration inhibitory factor: its potential anti‐inflammatory action
TLDR
Cetirizine, a putative H1‐receptor antagonist, has recently been shown to have anti‐inflammatory properties through the inhibition of leucocyte recruitment and activation, and by the reduction of ICAM‐1 expression on keratinocytes. Expand
Inverse agonists of H1-receptors as promising antiallergy agents (a review)
  • I. Gushchin
  • Chemistry
  • Pharmaceutical Chemistry Journal
  • 2010
The review summarizes published data and presents original results that illustrate the variety of antiallergic properties of second generation antihistamine drugs. General notions of inverse agonistsExpand
Antihistamines and their role as antipruritics
TLDR
H1 antihistamines have proven to be effective at reversing the pruritus and cutaneous lesions of chronic urticaria, but their ability to treatPruritus associated with other cutaneous and systemic diseases is unproven. Expand
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TLDR
It is suggested that prophylactic/long-term treatment with cetirizine and levocetirIZine may provide an opportunity to prevent/delay the development of asthma in susceptible individuals and to improve the QOL in patients with persistent AR. Expand
H 1 ANTIHISTAMINES IN ALLERGIC DISEASE
TLDR
Second-generation antihistamines are preferred to their predecessors because of better benefit-to-risk ratios, and are not only more potent, but also have anti-allergic and antiinflammatory properties. Expand
Anti‐inflammatory properties of desloratadine
  • D. Agrawal
  • Medicine
  • Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
  • 2004
Background Allergic rhinitis (AR) is associated with robust infiltration of immune cells and mediators that may contribute to clinical manifestations of the disease.
New oral H1 antihistamines in children: facts and unmeet needs
Background:  Second‐generation antihistamines differ from first‐generation ones because of their elevated specificity and affinity for peripheral H1‐receptors and because of their lower penetrationExpand
Antihistamines in pediatric allergy
TLDR
This review will highlight the characteristics of H1 antihistamines and their indications in pediatric allergic disorders. Expand
Comparative pharmacology of H1 antihistamines: clinical relevance.
  • F. Simons
  • Medicine
  • The American journal of medicine
  • 2002
TLDR
Understanding the pharmacokinetics and pharmacodynamics of these H1 antihistamines provides an objective basis for selection of appropriate dosages and dose intervals and provides a rationale for the modified dosage regimens that may be required in special populations, such as the very young, the elderly, those with hepatic or renal dysfunction, or those taking other medications concurrently. Expand
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