H-ras oncogene mutation and human papillomavirus infection in oral carcinomas.

@article{Anderson1994HrasOM,
  title={H-ras oncogene mutation and human papillomavirus infection in oral carcinomas.},
  author={Julie A Anderson and Jonathan C. Irish and C Megan McLachlin and Bo Yee Ngan},
  journal={Archives of otolaryngology--head & neck surgery},
  year={1994},
  volume={120 7},
  pages={755-60}
}
OBJECTIVE Previous in vitro studies have demonstrated that transfection of an activated ras gene induces malignant transformation in epithelial cell lines infected with the human papillomavirus (HPV). The results of these studies support the hypothesis that HPV may cooperate with an activated ras gene in epithelial tumor carcinogenesis. To test this hypothesis in head and neck cancers, we screened 35 oral carcinomas for the presence of HPV DNA and for a mutated H-ras gene. DESIGN The design… CONTINUE READING
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