H-ras but not K-ras traffics to the plasma membrane through the exocytic pathway.

@article{Apolloni2000HrasBN,
  title={H-ras but not K-ras traffics to the plasma membrane through the exocytic pathway.},
  author={Ann Apolloni and Ian A Prior and Margaret Lindsay and Robert G. Parton and John F Hancock},
  journal={Molecular and cellular biology},
  year={2000},
  volume={20 7},
  pages={2475-87}
}
Ras proteins must be localized to the inner surface of the plasma membrane to be biologically active. The motifs that effect Ras plasma membrane targeting consist of a C-terminal CAAX motif plus a second signal comprising palmitoylation of adjacent cysteine residues or the presence of a polybasic domain. In this study, we examined how Ras proteins access the cell surface after processing of the CAAX motif is completed in the endoplasmic reticulum (ER). We show that palmitoylated CAAX proteins… CONTINUE READING
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