H-ras but Not K-ras Traffics to the Plasma Membrane through the Exocytic Pathway

@article{Apolloni2000HrasBN,
  title={H-ras but Not K-ras Traffics to the Plasma Membrane through the Exocytic Pathway},
  author={Ann Apolloni and I. Prior and M. Lindsay and R. Parton and J. Hancock},
  journal={Molecular and Cellular Biology},
  year={2000},
  volume={20},
  pages={2475 - 2487}
}
  • Ann Apolloni, I. Prior, +2 authors J. Hancock
  • Published 2000
  • Biology, Medicine
  • Molecular and Cellular Biology
  • ABSTRACT Ras proteins must be localized to the inner surface of the plasma membrane to be biologically active. The motifs that effect Ras plasma membrane targeting consist of a C-terminal CAAX motif plus a second signal comprising palmitoylation of adjacent cysteine residues or the presence of a polybasic domain. In this study, we examined how Ras proteins access the cell surface after processing of the CAAX motif is completed in the endoplasmic reticulum (ER). We show that palmitoylated CAAX… CONTINUE READING
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