H-loop histidine catalyzes ATP hydrolysis in the E. coli ABC-transporter HlyB.

Abstract

Adenosine triphosphate (ATP)-binding cassette (ABC) transporters form a family of molecular motor proteins that couple ATP hydrolysis to substrate translocation across cell membranes. Each nucleotide binding domain of ABC-transporters contains a highly conserved H-loop histidine residue, whose precise mechanistic role in motor functions has remained elusive… (More)
DOI: 10.1039/c3cp50965f

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