H-7 effects on the structure and fluid conductance of monkey trabecular meshwork.

@article{Sabanay2000H7EO,
  title={H-7 effects on the structure and fluid conductance of monkey trabecular meshwork.},
  author={I Sabanay and B T Gabelt and Baohe Tian and Paul L. Kaufman and Benjamin Geiger},
  journal={Archives of ophthalmology},
  year={2000},
  volume={118 7},
  pages={955-62}
}
OBJECTIVE To determine the effects of H-7 (1-[5-isoquinoline sulfonyl]-2-methyl piperazine) on the structure and fluid conductance of the trabecular meshwork of live cynomolgus monkeys. METHODS Fluid outflow was measured by constant pressure perfusion of the anterior chamber with cationized and noncationized gold solution with or without H-7 in opposite eyes. The eyes were fixed by infusing Ito solution and enucleated. Anterior segments were cut into 4 sections, fixed in immersion solution… CONTINUE READING

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Rho GTPase-mediated actin cytoskeletal reorganization in outflow pathway cells may modulate outflow function [abstract

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