H₂O₂ stress-specific regulation of S. pombe MAPK Sty1 by mitochondrial protein phosphatase Ptc4.

@article{Di2012HOSR,
  title={H₂O₂ stress-specific regulation of S. pombe MAPK Sty1 by mitochondrial protein phosphatase Ptc4.},
  author={Yujun Di and Emily J. Holmes and Amna Butt and Keren Dawson and Aleksandr A Mironov and Vassilios N. Kotiadis and Campbell W Gourlay and Nic Jones and Caroline R. M. Wilkinson},
  journal={The EMBO journal},
  year={2012},
  volume={31 3},
  pages={563-75}
}
In fission yeast, the stress-activated MAP kinase, Sty1, is activated via phosphorylation upon exposure to stress and orchestrates an appropriate response. Its activity is attenuated by either serine/threonine PP2C or tyrosine phosphatases. Here, we found that the PP2C phosphatase, Ptc4, plays an important role in inactivating Sty1 specifically upon oxidative stress. Sty1 activity remains high in a ptc4 deletion mutant upon H(2)O(2) but not under other types of stress. Surprisingly, Ptc4… CONTINUE READING