H/D exchange mass spectrometry and statistical coupling analysis reveal a role for allostery in a ferredoxin-dependent bifurcating transhydrogenase catalytic cycle.

@article{Berry2018HDEM,
  title={H/D exchange mass spectrometry and statistical coupling analysis reveal a role for allostery in a ferredoxin-dependent bifurcating transhydrogenase catalytic cycle.},
  author={Luke Berry and Saroj Poudel and Monika Tokmina-Lukaszewska and Daniel R. Colman and Diep M. N. Nguyen and Gerrit J. Schut and Michael W W Adams and John W Peters and Eric S Boyd and Brian Bothner},
  journal={Biochimica et biophysica acta},
  year={2018},
  volume={1862 1},
  pages={9-17}
}
Recent investigations into ferredoxin-dependent transhydrogenases, a class of enzymes responsible for electron transport, have highlighted the biological importance of flavin-based electron bifurcation (FBEB). FBEB generates biomolecules with very low reduction potential by coupling the oxidation of an electron donor with intermediate potential to the… CONTINUE READING