H+ transport and coupling by the F0 sector of the ATP synthase: insights into the molecular mechanism of function.

@article{Fillingame1992HTA,
  title={H+ transport and coupling by the F0 sector of the ATP synthase: insights into the molecular mechanism of function.},
  author={Robert H. Fillingame},
  journal={Journal of bioenergetics and biomembranes},
  year={1992},
  volume={24 5},
  pages={485-91}
}
The F0 sector of the ATP synthase complex facilitates proton translocation through the membrane, and via interaction with the F1 sector, couples proton transport to ATP synthesis. The molecular mechanism of function is being probed by a combination of mutant analysis and structural biochemistry, and recent progress on the Escherichia coli F0 sector is reviewed here. The E. coli F0 is composed of three types of subunits (a, b, and c) and current information on their folding and organization in… CONTINUE READING