H+ gradient-dependent transport of aminocephalosporins in rat renal brush border membrane vesicles: role of H+/organic cation antiport system.

@article{Inui1985HGT,
  title={H+ gradient-dependent transport of aminocephalosporins in rat renal brush border membrane vesicles: role of H+/organic cation antiport system.},
  author={Ken-ichi Inui and Mikihisa Takano and Teruo Okano and Ryohei Hori},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1985},
  volume={233 1},
  pages={181-5}
}
The transport of aminocephalosporin antibiotics such as cephalexin, zwitterion, by rat renal brush border membrane vesicles has been studied in relation to the transport system of organic cation. Cephalexin uptake was inhibited by organic cations such as tetraethylammonium, 1N-methylnicotinamide and choline, whereas cefazolin uptake was not. Tetraethylammonium uptake was inhibited by aminocephalosporins and stimulated by the countertransport effect of cephalexin. In agreement with the transport… CONTINUE READING