Corpus ID: 2107472

H+ gradient-dependent and carrier-mediated transport of cefixime, a new cephalosporin antibiotic, across brush-border membrane vesicles from rat small intestine.

@article{Tsuji1987HGA,
  title={H+ gradient-dependent and carrier-mediated transport of cefixime, a new cephalosporin antibiotic, across brush-border membrane vesicles from rat small intestine.},
  author={A. Tsuji and T. Terasaki and I. Tamai and H. Hirooka},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1987},
  volume={241 2},
  pages={
          594-601
        }
}
The characteristics of the transport of cefixime, a new p.o. cephalosporin, antibiotic, were studied by using brush-border membrane vesicles from the rat small intestine. The initial rate of uptake of cefixime was not affected by the presence of an inward gradient of either Na+ or other monovalent cations. With an intravesicular pHi of 7.5, optimal cefixime uptake occurred at an extravesicular pHo of 5.0, with about 6-fold acceleration compared with that in the absence of an inward proton… Expand
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