H+-dependent sulfate secretion in the marine teleost renal tubule.

  title={H+-dependent sulfate secretion in the marine teleost renal tubule.},
  author={J. Larry Renfro and John B. Pritchard},
  journal={The American journal of physiology},
  volume={243 2},
Renal sulfate secretion was studied in the southern flounder Paralichthys lethostigma. In the intact animal sulfate clearance averaged 12 times the glomerular filtration rate and about 93% of the excreted sulfate was secreted. The secretory maximum was 150 mumol . kg body wt-1 . h-1 at 5 mM plasma sulfate. DIDS inhibited sulfate secretion in vivo. In vitro sulfate uptake by renal tubule fragments was saturable (Km = 0.92 mM) and could be inhibited by DIDS, SITS, and antimycin A. Na-free medium… CONTINUE READING