H(2)O(2) mediates Ca(2+)- and MLC(20) phosphorylation-independent contraction in intact and permeabilized vascular muscle.

@article{Pelaez2000H2O2MC,
  title={H(2)O(2) mediates Ca(2+)- and MLC(20) phosphorylation-independent contraction in intact and permeabilized vascular muscle.},
  author={Nancy J Pelaez and Thomas R. Braun and R. J. Birch Paul and Richard Alan Meiss and Caroline Packer},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2000},
  volume={279 3},
  pages={
          H1185-93
        }
}
One purpose of the current study was to establish whether vasoconstriction occurs in all vessel types in response to H(2)O(2). Isometric force was measured in pulmonary venous and arterial rings, and isobaric contractions were measured in mesenteric arteries and veins in response to H(2)O(2). A second purpose was to determine whether H(2)O(2)-induced contraction is calcium independent. The addition of H(2)O(2) to calcium-depleted (using the Ca(2+) ionophore ionomycin in zero calcium EGTA buffer… CONTINUE READING

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creased exhalation of hydrogen peroxide in patients with stable and unstable chronic obstructive pulmonary disease

  • Dekhuijzen PNR, Aben KKH, +4 authors A Bast
  • Am J Re - spir Crit Care Med
  • 1996

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