H(+)-linked transport of salicylic acid, an NSAID, in the human trophoblast cell line BeWo.

@article{Emoto2002HlinkedTO,
  title={H(+)-linked transport of salicylic acid, an NSAID, in the human trophoblast cell line BeWo.},
  author={Akiko Emoto and Fumihiko Ushigome and Noriko Koyabu and Hiroshi Kajiya and Koji Okabe and Shoji Satoh and Kiyomi Tsukimori and Hitoo Nakano and Hisakazu Ohtani and Yasufumi Sawada},
  journal={American journal of physiology. Cell physiology},
  year={2002},
  volume={282 5},
  pages={C1064-75}
}
We investigated the transport of salicylic acid and L-lactic acid across the placenta using the human trophoblast cell line BeWo. We performed uptake experiments and measured the change in intracellular pH (pH(i)). The uptakes of [(14)C]salicylic acid and L-[(14)C]lactic acid were temperature- and extracellular pH-dependent and saturable at higher concentrations. Both uptakes were also reduced by FCCP, nigericin, and NaN(3). Various nonsteroidal anti-inflammatory drugs (NSAIDs) strongly… CONTINUE READING

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