Gypenosides suppress growth of human oral cancer SAS cells in vitro and in a murine xenograft model: the role of apoptosis mediated by caspase-dependent and caspase-independent pathways.

@article{Lu2012GypenosidesSG,
  title={Gypenosides suppress growth of human oral cancer SAS cells in vitro and in a murine xenograft model: the role of apoptosis mediated by caspase-dependent and caspase-independent pathways.},
  author={K Lu and J C Chen and Tung-Yuan Lai and J. Yang and Shu-Wen Weng and Yi-Shih Ma and Hui-Yi Lin and Rick Sai-Chuan Wu and King-Chuen Wu and Wellington Gibson Wood and Jing-Gung Chung},
  journal={Integrative cancer therapies},
  year={2012},
  volume={11 2},
  pages={129-40}
}
PURPOSE Gypenosides (Gyp) are the major components of Gynostemma pentaphyllum Makino. The authors investigated the effects of Gyp on cell morphology, viability, cell cycle distribution, and induction of apoptosis in human oral cancer SAS cells and the determination of murine SAS xenograft model in vivo. EXPERIMENTAL DESIGN Flow cytometry was used to quantify the percentage of viable cells; cell cycle distribution; sub-G1 phase (apoptosis); caspase-3, -8, and -9 activity; reactive oxygen… CONTINUE READING
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