Gynaecomastia without lipodystrophy in HIV-1-seropositive patients on efavirenz: an alternative hypothesis.

  title={Gynaecomastia without lipodystrophy in HIV-1-seropositive patients on efavirenz: an alternative hypothesis.},
  author={Nadeem A Qazi and John F. Morlese and David M King and Rizvana S Ahmad and Brian George Gazzard and Mark R. Nelson},
  volume={16 3},
Efavirenz-induced gynecomastia in a prepubertal girl with human immunodeficiency virus infection: a case report
Timely recognition of gynecomastia as a side-effect of efavirenz is important in order to intervene while the condition may still be reversible, to sustain adherence to ART and to maintain the sociopsychological health of the child. Expand
Efavirenz-induced gynaecomastia in HIV-infected Nigerian men: A report of six cases
Six patients presenting in the treatment program with varying degrees of gynaecomastia following the use of efavirenz-based highly active antiretroviral therapy, despite adequate immunologic and virologic response are reported. Expand
A case series of efavirenz induced gynaecomastia
The present study presented a series of two cases that developed ultrasound confirmed gynaecomastia following efavirenz containing HAART, and suggested that proper identification and management will promote better drug adherence. Expand
Efavirenz induced gynecomastia, hidden reality: a case series
The incidence of gynaecomastia is increasing in men with HIV on HAART therapy, proper identification and management will promote better drug adherence. Expand
Gynaecomastia in the Durban Breast Unit: A Comparison of HIV- and Non-HIV-Infected Individuals
Patients on HAART are advised to seek early advice upon noticing gynaecomastia and management option must be discussed with patients, and surgeons are required to be familiar with the various surgical techniques necessary to treat gynaEComastsia. Expand
Breast abnormalities in adolescents receiving antiretroviral therapy
The use of EFV and increased age were associated with breast abnormalities in this population of adolescents receiving antiretroviral therapy and further research is needed to better understand the implications of this potential side effect. Expand
Gynecomastia in HIV-positive adult men receiving efavirenz-based antiretroviral therapy at Newlands clinic, Harare, Zimbabwe
The incidence of gynecomastia among patients taking efavirenz-based ART was low with most cases developing early on during treatment and most cases resolved completely after withdrawing efvirenz. Expand
HIV-infected adolescents on anti-retroviral therapy: a retrospective descriptive cohort study of breast abnormalities documented during routine care
A research report submitted in submissible format to the Faculty of Health Sciences, University of Witwatersrand, Johannesburg, in partial fulfillment of the requirements for the degree of MSc inExpand
Who Gets Severe Gynecomastia Among HIV-infected Children in the United Kingdom and Ireland?
Five HIV-infected children in the UK/Ireland’s national cohort had gynecomastia, of which five were nonreversible, despite changing antiretroviral therapy, and required breast reduction surgery. Expand
Cases of antiretroviral-associated gynaecomastia reported to the National HIV & Tuberculosis Health Care Worker Hotline in South Africa
Gynaecomastia was a frequently reported ADR in the setting, occurring with prolonged efavirenz exposure, and most clinicians elected to switch patients off efvirenz, and gynaecamastia improved in the majority. Expand


Assessment of type 1 and type 2 cytokines in HIV type 1-infected individuals: impact of highly active antiretroviral therapy.
Evidence of changes in expression of type 1 and type 2 cytokine-specific mRNA occurring during HIV-1 infection, before and after initiation of HAART is provided to suggest that in addition to suppressing virus replication directly the immune system may be given a chance to recover. Expand
The regulation of aromatase activity in breast fibroblasts: the role of interleukin-6 and prostaglandin E2.
In some fibroblasts PGE2 may exert part of its regulatory effect on breast tissue aromatase activity via induction of IL-6, which was confirmed by measurement ofIL-6 in conditioned medium collected from cells treated with P GE2. Expand
Ultrasound mammography for male breast enlargement.
Among nine cases of men who underwent excision, there were six cases of gynecomastia, two lipomas, and one biopsy revealed normal subcutaneous tissue. Expand