Gynaecomastia—pathophysiology, diagnosis and treatment

@article{Narula2014GynaecomastiapathophysiologyDA,
  title={Gynaecomastia—pathophysiology, diagnosis and treatment},
  author={Harmeet S. Narula and HAROLD E. Carlson},
  journal={Nature Reviews Endocrinology},
  year={2014},
  volume={10},
  pages={684-698}
}
Gynaecomastia (enlargement of the male breast tissue) is a common finding in the general population. Most cases of gynaecomastia are benign and of cosmetic, rather than clinical, importance. However, the condition might cause local pain and tenderness, could occasionally be the result of a serious underlying illness or a medication, or be inherited. Breast cancer in men is much less common than benign gynaecomastia, and the two conditions can usually be distinguished by a careful physical… 

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References

SHOWING 1-10 OF 224 REFERENCES

Gynaecomastia and breast cancer in men

The causes, evaluation, and treatment of gynaecomastia, the benign enlargement of male breast tissue resulting from a relative decrease in androgen effect or increase in oestrogen effect is reviewed.

Incidence and management of gynecomastia in men treated for prostate cancer.

Gynecomastia is a significant problem in men undergoing hormonal therapy for prostate cancer and requires prompt recognition, evaluation and management.

Pathological Findings in Gynecomastia: Analysis of 5113 Breasts

The prevalence of malignancies in GM resection specimens is low; however, it increases with patient age, particularly in patients younger than 20 years.

Gynecomastia and hyperthyroidism.

Tender breast enlargement is called attention to as one manifestation of the symptomatology of Graves’ disease itself and 4 such cases in males observed in the past one and a half years among a total of 45 cases of hyperthyroidism examined during this period.

Approach to the patient with gynecomastia.

  • H. Carlson
  • Medicine
    The Journal of clinical endocrinology and metabolism
  • 2011
Although rare, male breast cancer must also be considered in the differential diagnosis, a careful diagnostic evaluation should be pursued, tailored to the individual patient's circumstances.

Gynecomastia as a physical finding in normal men.

  • F. Nuttall
  • Medicine
    The Journal of clinical endocrinology and metabolism
  • 1979
The data indicate that palpable gynecomastic is common in normal adult men and this high prevalence must be taken into consideration when attributingGynecomastia to a drug or disease state.

Multimodality Treatment of Gynecomastia in Patients Receiving Antiandrogen Therapy for Prostate Cancer in the Era of Abiraterone Acetate and New Antiandrogen Molecules

This article focuses on gynecomastia associated with antiandrogen-based hormonal treatment and shortly reviews the currently most often used therapeutic options for preventing and treating this pathology.

Gynecomastia: clinicopathologic study of 351 cases.

It is postulated that the hyperplastic breast tissue undergoes a process of maturation or senescence, proceeding from the florid to the fibrous type, irrespective of etiologic factor.
...