Gynaecomastia: The Anastrozole Paradox

@article{Bedognetti2010GynaecomastiaTA,
  title={Gynaecomastia: The Anastrozole Paradox},
  author={Davide Bedognetti and Alessandra Rubagotti and Gabriele Zoppoli and Francesco Boccardo},
  journal={Journal of Pediatric Endocrinology and Metabolism},
  year={2010},
  volume={23},
  pages={205 - 206}
}
Recently, Mauras et al. published the results of a clinical trial evaluating the pharmacokinetics of oral anastrozole (an aromatase inhibitor) in adolescent males with gynaecomastia. The authors evaluated 42 boys (11-15 years old) with early onset gynaecomastia (4:5-10.5 months) treated with anastrozole (1 mg daily) for 6 months. Mauras and coworkers found that anastrozole had rapid absorption and slow elimination kinetics, and caused testosterone/oestradiol to increase, proving its aromatase… Expand
1 Citations
Drug‐Induced Gynecomastia
TLDR
Antiandrogens, protease inhibitors, and nucleoside reverse transcriptase inhibitors are the most common drug causes of gynecomastia, whereas first‐generation antipsychotics, spironolactone, verapamil, and cimetidine are less common causes. Expand

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