Gynaecological cancer: PARP inhibition — moving beyond BRCA-mutated disease

Abstract

cells with homologous-recombination deficiency (HRD), and PARP inhibitors have proven therapeutic activity in women with BRCA-mutated ovarian cancer. This group, however, accounts for only ~20% of patients with ovarian cancer. Importantly, approximately 30% of women with this disease have HRD of a different aetiology, and might also benefit from PARP… (More)
DOI: 10.1038/nrclinonc.2016.207

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