Gynaecological and obstetrical morbidity in women with type I von Willebrand disease: results of a patient survey

@article{Kouides2000GynaecologicalAO,
  title={Gynaecological and obstetrical morbidity in women with type I von Willebrand disease: results of a patient survey},
  author={Peter A Kouides and Pradyumna D. Phatak and Peter T. Burkart and Caroline Braggins and Christopher Cox and Z Bernstein and Linda Belling and Peter J. Holmberg and W. Maclaughlin and Fred M. Howard},
  journal={Haemophilia},
  year={2000},
  volume={6}
}
Type 1 von Willebrand disease (vWD) is generally regarded clinically as ‘mild’ and the obstetrical–gynaecological features have not been fully described. We administered a patient questionnaire and provider survey of the medical and quality of life aspects of childbirth and menstruation to 99 type 1 vWD patients and compared the patients presently menstruating (n=81) to a cohort of 150 menstruating females in the general population. The following measurements had a statistically higher… Expand
Gynaecological and obstetric bleeding in moderate and severe von Willebrand disease.
TLDR
It is concluded that women with moderate or severe VWD frequently have menorrhagia in need of treatment, and 20% of the VWD women underwent a hysterectomy predominantly because of severe menstrual bleeding. Expand
Obstetric and gynaecological aspects of von Willebrand disease.
  • P. Kouides
  • Medicine
  • Best practice & research. Clinical haematology
  • 2001
TLDR
Studies over the past decade have documented a substantial impact of menses and childbirth on von Willebrand disease patients, which should serve as a basis for interventional studies to reduce the morbidity of menstruation and childbirth. Expand
Von Willebrand disease in women: awareness and diagnosis.
TLDR
Adequate prophylaxis during surgery and childbirth may help to prevent bleeding complications in women with VWD and several medical and surgical treatment options are available for menorrhagia. Expand
von Willebrand Disease: Prevention of Complications and Management of the Disease
Von Willebrand disease (VW) is a bleeding disorder that the clinician must learn particularly well as it is relatively common (1:1000) (Bowman et al. 2005), and unlike hemophilia, it is in many waysExpand
Problemy ginekologiczno-położnicze w chorobie von Willebranda The gynaecological and obstetric issues of von Willebrand disease
TLDR
The purpose of this paper is to discuss the treatment of gynaecological and obstetrical complications of von Willebrand disease. Expand
Postpartum Hemorrhage in Women with Von Willebrand Disease – A Retrospective Observational Study
TLDR
Investigating the incidence of PPH in women with VWD and the correlation between PPH and type of VWD found type 3 VWD was associated with a higher risk of experiencing severe primary PPH compared to other subtypes, and FVIII:C in pregnancy was inversely correlated to blood loss during delivery. Expand
Women with von Willebrand disease.
TLDR
During menopause the clinical situation improves for most of the women with mild or moderate VWD, and in severe forms of VWD the bleeding risk is high during delivery and postpartum period. Expand
No. 163-Gynaecological and Obstetric Management of Women With Inherited Bleeding Disorders.
OBJECTIVE The prevalence of bleeding disorders, notably von Willebrand disease (vWD), among adult women with objectively documented menorrhagia is consistently reported to be 10% to 20% and is evenExpand
Current understanding of von Willebrand's disease in women – some answers, more questions
  • P. Kouides
  • Medicine
  • Haemophilia : the official journal of the World Federation of Hemophilia
  • 2006
TLDR
A review of the present state of knowledge of von Willebrand's disease in women highlights numerous questions for future study based on the present understanding of VWD in women. Expand
Significant gynecological bleeding in women with low von Willebrand factor levels.
TLDR
It is demonstrated that gynecological bleeding is frequently reported in women with low VWF; despite pregnancy-related increases in plasma VWF levels, these women may experience PPH; Defining the optimal management approach for these patients requires further research. Expand
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References

SHOWING 1-10 OF 23 REFERENCES
Assessment of menstrual blood loss and gynaecological problems in patients with inherited bleeding disorders
TLDR
Menorrhagia is a common and major problem in patients with inherited bleeding disorders, especially vWD, and Appropriate preoperative assessment and haemostatic control during any gynaecological procedure is essential to minimize risks of haemorrhagic complications. Expand
Quality of life during menstruation in patients with inherited bleeding disorders
Menorrhagia is a common and major problem for patients with inherited bleeding disorders, especially vWD. Quality of life during menstruation was assessed in 99 patients with inherited bleedingExpand
Obstetric management in von Willebrand's disease: a report of 24 pregnancies and a reivesw of the literature
The case records of 13 patients (24 pregnancies) with von Willebrand's disease (vWD) were studies rettospectively. The overall incidence of primary and secondary post‐partum haemorrhage (PPH) wasExpand
The reproductive health of women with von Willebrand Disease unresponsive to DDAVP: results of an international survey. On behalf of the Subcommittee on von Willebrand Factor of the Scientific and Standardization Committee of the ISTH.
  • P. Foster
  • Medicine
  • Thrombosis and haemostasis
  • 1995
TLDR
An international registry was established on the reproductive health of women with types of von Willebrand disease unresponsive to DDAVP, finding that OC therapy was clinically effective in the treatment of chronic menorrhagia in 22 of 25 women treated. Expand
Frequency of inherited bleeding disorders in women with menorrhagia
TLDR
Inherited bleeding disorders are found in a substantial proportion of women with menorrhagia and a normal pelvis examination and it is suggested that such patients should be investigated for these disorders-especially von Willebrand's disease-before invasive procedures are done. Expand
Prevalence of von Willebrand disease in children: a multiethnic study.
TLDR
Von Willebrand disease is the most common congenital hemostatic disorder; its high prevalence is not limited to one ethnic group. Expand
von Willebrand disease and bleeding in women
TLDR
Menorrhagia is the most common bleeding symptom in females with vWD and begins at menarche, and obtaining a personal and family bleeding history promotes early diagnosis, potentially prevents postoperative bleeding, and improves the health of women with v WD. Expand
Epidemiological investigation of the prevalence of von Willebrand's disease.
TLDR
The results suggest that the prevalence of von Willebrand's disease (vWd) might be much higher than previously reported and that a different screening approach might be of use for patients with mild bleeding diathesis. Expand
On the value of menorrhagia as a predictor for coagulation disorders
TLDR
It is concluded that menorrhagia is a valuable predictor for coagulation and platelet disorders, and that time of sampling is of importance, and can be a guideline in looking for mild bleeding disorders. Expand
Pregnancy in von Willebrand's disease.
TLDR
Dr Robertson and colleagues must be congratulated for holding up the "red flag of classification" to the "bulls of gynaecological cytology" as the frailty of the current reporting system becomes increasingly evident. Expand
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