Gymnemic acids lozenge reduces short-term consumption of high-sugar food: A placebo controlled experiment

@article{Stice2017GymnemicAL,
  title={Gymnemic acids lozenge reduces short-term consumption of high-sugar food: A placebo controlled experiment},
  author={Eric Stice and Sonja Yokum and Jeff M. Gau},
  journal={Journal of Psychopharmacology},
  year={2017},
  volume={31},
  pages={1496 - 1502}
}
Gymnemic acids (GA) suppress sweet taste and reduce consumption of high-sugar foods (HSF) which has been attributed to the reduction in pleasure. Herein we tested whether GA reduces the desire to eat HSF, before any HSF is tasted post GA dosing, which would implicate another mechanism of action not previously examined. In this double-blind experiment, 67 adults selected a favourite candy, consumed one standardized serving, rated candy pleasantness along with desire for more candy, and were… Expand
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References

SHOWING 1-10 OF 22 REFERENCES
Effects of sweetness perception and caloric value of a preload on short term intake
TLDR
The findings indicate that hedonistic aspects of taste are of greater importance than calories in determining short term intake in subjects fasted normal weight subjects drinking a preload sweetened with sucrose or L-asparthyl-L-phenylalanyl-methyl ester. Expand
Psychoactive effects of tasting chocolate and desire for more chocolate
TLDR
It is suggested that multiple characteristics of chocolate, including sugar, cocoa and the drug-like effects experienced, play a role in the desire to consume chocolate. Expand
Taste confusions following gymnemic acid rinse.
TLDR
The results suggest that specific error patterns in the TCM could be used to identify quality-specific taste disorders. Expand
Sleep curtailment is accompanied by increased intake of calories from snacks.
TLDR
Recurrent bedtime restriction can modify the amount, composition, and distribution of human food intake, and sleeping short hours in an obesity-promoting environment may facilitate the excessive consumption of energy from snacks but not meals. Expand
Sucrose sham feeding on a binge schedule releases accumbens dopamine repeatedly and eliminates the acetylcholine satiety response
TLDR
The taste of sugar can increase extracellular dopamine in the nucleus accumbens without fail in animals on a dietary regimen that causes bingeing and sugar dependency, and this support the hypothesis that dopamine is released repeatedly in response to taste when bingeing on sweet food. Expand
Acute partial sleep deprivation increases food intake in healthy men.
TLDR
It is suggested that sleep restriction could be a factor that promotes obesity and, to a lesser extent, estimated physical activity-related energy expenditure in healthy men. Expand
Taste in chimpanzee: I. The summated response to sweeteners and the effect of gymnemic acid
TLDR
The results demonstrated that after exposure of the tongue to GA, the animals' liking for sweet diminished, which parallel psychophysical and electrophysiological findings in humans. Expand
Sugar-sweetened beverages and weight gain in children and adults: a systematic review and meta-analysis.
TLDR
Sensitivity analyses of RCTs in children showed more pronounced benefits in preventing weight gain in SSB substitution trials (compared with school-based educational programs) and among overweight children (comparing with normal-weight children). Expand
Effects of gymnemic acid on the chorda tympani proper nerve responses to sweet, sour, salty and bitter taste stimuli in the chimpanzee.
TLDR
This study presents chorda tympani proper nerve recordings from the chimpanzee before and after gymnemic acid, finding that after application of 2 ml miraculin, 3 mg X ml-1 for 3 min to the tongue the neural response to acids was about 1.5 times as large as before. Expand
Molecular Mechanisms for Sweet-suppressing Effect of Gymnemic Acids*
TLDR
Using mixed species pairings of human and mouse sweet receptor subunits and chimeras, it is determined that the transmembrane domain of hT1R3 was mainly required for the sweet-suppressing effect of gymnemic acids. Expand
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