Gymnemic acids lozenge reduces short-term consumption of high-sugar food: A placebo controlled experiment

  title={Gymnemic acids lozenge reduces short-term consumption of high-sugar food: A placebo controlled experiment},
  author={Eric Stice and Sonja Yokum and Jeff M. Gau},
  journal={Journal of Psychopharmacology},
  pages={1496 - 1502}
Gymnemic acids (GA) suppress sweet taste and reduce consumption of high-sugar foods (HSF) which has been attributed to the reduction in pleasure. Herein we tested whether GA reduces the desire to eat HSF, before any HSF is tasted post GA dosing, which would implicate another mechanism of action not previously examined. In this double-blind experiment, 67 adults selected a favourite candy, consumed one standardized serving, rated candy pleasantness along with desire for more candy, and were… Expand
Crave CrushTM lozenges containing gymnemic acids reduce consumption of high sugar foods
Reduction in sugar intake can have a positive effect on body weight and increased intake a negative impact. Gymnemic acids (GA) are antagonists at tongue glucose receptors thus blunting sweet taste.Expand
Consuming Gymnema sylvestre Reduces the Desire for High-Sugar Sweet Foods
Consuming gymnema-containing mints compared to placebo significantly reduced the quantity of chocolate eaten mainly due to a decrease in the desire and pleasantness of consuming it. Expand
Effects of gymnemic acids lozenge on reward region response to receipt and anticipated receipt of high-sugar food
Results suggest that the gymnemic acids lozenge might prove useful in decreasing high-sugar food intake, potentially via a feedback loop regarding the availability of sweet taste receptors to convey perceptual input regarding sweet tastes. Expand
Suppression of Oral Sweet Sensations during Consumption of Sweet Food in Humans: Effects on Gastric Emptying Rate, Glycemic Response, Appetite, Food Satisfaction and Desire for Basic Tastes
It is suggested that the suppression of OSS does not affect gastric emptying, glycemic response and appetite during and after consumption of sweet-tasting food. Expand
Pathways and mechanisms linking dietary components to cardiometabolic disease: thinking beyond calories
  • K. Stanhope, M. Goran, +19 authors R. Krauss
  • Medicine
  • Obesity reviews : an official journal of the International Association for the Study of Obesity
  • 2018
It is concluded that food‐specific saturated fatty acids and sugar‐sweetened beverages promote cardiometabolic diseases by mechanisms that are additional to their contribution of calories to positive energy balance and that aspartame does not promote weight gain. Expand
Preparation, optimization and biological evaluation of gymnemic acid loaded niosomes against streptozotocin-nicotinamide induced diabetic-nephropathy in Wistar rats
Abstract The present study was designed to develop and evaluate the gymnemic acid (GA)-loaded niosomes against “streptozotocin-nicotinamide” (STZ-NA) induced “diabetic nephropathy” (DN) in WistarExpand
Multidisciplinary approaches to the study of eating disorders and obesity: Recent progress in research and development and future prospects
Identification of risk factors for disordered eating in general population samples may have a significant impact on public health and could help in both the prevention and treatment of eating disorders. Expand
An Exploration of the Role of Sugar-Sweetened Beverage in Promoting Obesity and Health Disparities
Current scientific evidence strongly suggests that proactive environmental measures to reduce exposure to palatable food cues in the form of targeting marketing will decrease the risk of obesity in vulnerable populations. Expand


Effects of sweetness perception and caloric value of a preload on short term intake
The findings indicate that hedonistic aspects of taste are of greater importance than calories in determining short term intake in subjects fasted normal weight subjects drinking a preload sweetened with sucrose or L-asparthyl-L-phenylalanyl-methyl ester. Expand
Psychoactive effects of tasting chocolate and desire for more chocolate
It is suggested that multiple characteristics of chocolate, including sugar, cocoa and the drug-like effects experienced, play a role in the desire to consume chocolate. Expand
Taste confusions following gymnemic acid rinse.
The results suggest that specific error patterns in the TCM could be used to identify quality-specific taste disorders. Expand
Sleep curtailment is accompanied by increased intake of calories from snacks.
Recurrent bedtime restriction can modify the amount, composition, and distribution of human food intake, and sleeping short hours in an obesity-promoting environment may facilitate the excessive consumption of energy from snacks but not meals. Expand
Sucrose sham feeding on a binge schedule releases accumbens dopamine repeatedly and eliminates the acetylcholine satiety response
The taste of sugar can increase extracellular dopamine in the nucleus accumbens without fail in animals on a dietary regimen that causes bingeing and sugar dependency, and this support the hypothesis that dopamine is released repeatedly in response to taste when bingeing on sweet food. Expand
Acute partial sleep deprivation increases food intake in healthy men.
It is suggested that sleep restriction could be a factor that promotes obesity and, to a lesser extent, estimated physical activity-related energy expenditure in healthy men. Expand
Taste in chimpanzee: I. The summated response to sweeteners and the effect of gymnemic acid
The results demonstrated that after exposure of the tongue to GA, the animals' liking for sweet diminished, which parallel psychophysical and electrophysiological findings in humans. Expand
Sugar-sweetened beverages and weight gain in children and adults: a systematic review and meta-analysis.
Sensitivity analyses of RCTs in children showed more pronounced benefits in preventing weight gain in SSB substitution trials (compared with school-based educational programs) and among overweight children (comparing with normal-weight children). Expand
Effects of gymnemic acid on the chorda tympani proper nerve responses to sweet, sour, salty and bitter taste stimuli in the chimpanzee.
This study presents chorda tympani proper nerve recordings from the chimpanzee before and after gymnemic acid, finding that after application of 2 ml miraculin, 3 mg X ml-1 for 3 min to the tongue the neural response to acids was about 1.5 times as large as before. Expand
Molecular Mechanisms for Sweet-suppressing Effect of Gymnemic Acids*
Using mixed species pairings of human and mouse sweet receptor subunits and chimeras, it is determined that the transmembrane domain of hT1R3 was mainly required for the sweet-suppressing effect of gymnemic acids. Expand