Guts and Gall: Bile Acids in Regulation of Intestinal Epithelial Function in Health and Disease.

@article{Hegyi2018GutsAG,
  title={Guts and Gall: Bile Acids in Regulation of Intestinal Epithelial Function in Health and Disease.},
  author={P. Hegyi and J. Mal{\'e}th and J. Walters and A. F. Hofmann and S. Keely},
  journal={Physiological reviews},
  year={2018},
  volume={98 4},
  pages={
          1983-2023
        }
}
  • P. Hegyi, J. Maléth, +2 authors S. Keely
  • Published 2018
  • Physics, Medicine
  • Physiological reviews
  • Epithelial cells line the entire surface of the gastrointestinal tract and its accessory organs where they primarily function in transporting digestive enzymes, nutrients, electrolytes, and fluid to and from the luminal contents. At the same time, epithelial cells are responsible for forming a physical and biochemical barrier that prevents the entry into the body of harmful agents, such as bacteria and their toxins. Dysregulation of epithelial transport and barrier function is associated with… CONTINUE READING
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    References

    SHOWING 1-10 OF 511 REFERENCES
    Bile acids in the colon, from healthy to cytotoxic molecules.
    • 97
    Intestinal transport and metabolism of bile acids
    • 201
    • PDF
    Roles of Ileal ASBT and OSTα-OSTβ in Regulating Bile Acid Signaling
    • 16
    The intestinal epithelium is an integral component of a communications network.
    • M. Kagnoff
    • Medicine, Biology
    • The Journal of clinical investigation
    • 2014
    • 61
    • PDF
    Intestinal barrier in inflammatory bowel disease.
    • 165
    Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor.
    • 684
    • PDF
    Epithelial barriers in homeostasis and disease.
    • 422
    Neuro‐humoral signalling by bile acids and the TGR5 receptor in the gastrointestinal tract
    • N. Bunnett
    • Biology, Medicine
    • The Journal of physiology
    • 2014
    • 44
    Secretory IgA's complex roles in immunity and mucosal homeostasis in the gut
    • 617
    • PDF