Gut permeability and mucosal inflammation: bad, good or context dependent

  title={Gut permeability and mucosal inflammation: bad, good or context dependent},
  author={Raise Ahmad and Michael F. Sorrell and Surinder Batra and Punita Dhawan and Amar Bahadur Singh},
  journal={Mucosal Immunology},
Inflammatory bowel disease (IBD) is a multifactorial disease. A breach in the mucosal barrier, otherwise known as “leaky gut,” is alleged to promote mucosal inflammation by intensifying immune activation. However, interaction between the luminal antigen and mucosal immune system is necessary to maintain mucosal homeostasis. Furthermore, manipulations leading to deregulated gut permeability have resulted in susceptibility in mice to colitis as well as to creating adaptive immunity. These… CONTINUE READING
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