Gut permeability, its interaction with gut microflora and effects on metabolic health are mediated by the lymphatics system, liver and bile acid.

@article{Tran2015GutPI,
  title={Gut permeability, its interaction with gut microflora and effects on metabolic health are mediated by the lymphatics system, liver and bile acid.},
  author={Cuong Danh Tran and Desma M. Grice and Ben Wade and Caroline A. Kerr and Denis C. Bauer and Dongmei Li and Garry N. Hannan},
  journal={Future microbiology},
  year={2015},
  volume={10 8},
  pages={
          1339-53
        }
}
There is evidence to link obesity (and metabolic syndrome) with alterations in gut permeability and microbiota. The underlying mechanisms have been questioned and have prompted this review. We propose that the gut barrier function is a primary driver in maintaining metabolic health with poor health being linked to 'gut leakiness'. This review will highlight changes in intestinal permeability and how it may change gut microflora and subsequently affect metabolic health by influencing the… 
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The present review will highlight the role of microorganisms in host energy regulation and several mechanisms that contribute to inflammatory pathways, and discuss the immunomodulatory effects of the endocannabinoid system and its link with the gut microbiota.
Changes in intestinal microbiota composition and metabolism coincide with increased intestinal permeability in young adults under prolonged physiological stress.
TLDR
It is demonstrated that a multiple-stressor military training environment induced increases in IP that were associated with alterations in markers of inflammation and with intestinal microbiota composition and metabolism, and targeting the intestinal microbiota could provide novel strategies for mitigating increases in intestinal permeability during stress.
High-Throughput Screen Identifies Host and Microbiota Regulators of Intestinal Barrier Function.
TLDR
Molecules that disrupt and stabilize intestinal epithelial TJs and barrier function and affect development of colon inflammation in mice are identified and might be developed for treatment of barrier intestinal impairment-associated and inflammatory disorders in patients, or avoided to prevent inflammation.
The Relationship among Physical Activity, Intestinal Flora, and Cardiovascular Disease
TLDR
The impacts of different types of PA on intestinal microflora including the diversity, distribution, metabolites, and intestinal barrier function including intestinal permeability are discussed, with a focus on the mechanisms by which PA affects GM.
Helicobacter pylori Infection Aggravates Diet-induced Insulin Resistance in Association With Gut Microbiota of Mice
Bioaccessibility and Bioactivity of Cereal Polyphenols: A Review
TLDR
The therapeutic value of cereal polyphenols in conjunction with their bioaccessibility, impact on intestinal barrier function and interaction with the microbiome coupled with plasma anti-inflammatory effects are explored.
Impact of diet and synbiotics on selected gut bacteria and intestinal permeability in individuals with excess body weight - A Prospective, Randomized Study.
TLDR
The use of diet and synbiotics improved the condition of the microbiota and intestinal barrier in patients in the Synbiotic group, and there were no significant relationships between the body mass, BMI and changes in the intestinal microbiota or zonulin concentrations.
Alterations in fecal short-chain fatty acids in patients with irritable bowel syndrome
TLDR
A meta-analysis of case-control studies, randomized controlled trials, and self-controlled studies revealed differences between patients with IBS and HCs in terms of fecal SCFAs, and found that restricted diets correlated with fecal butyrate reduction in IBS, suggesting propionate andbutyrate could be used as biomarkers for IBS diagnosis.
Intestinal barrier function in obesity with or without metabolic syndrome: a systematic review protocol
TLDR
A systematic review protocol investigating if obesity with or without metabolic syndrome is associated with an altered intestinal barrier function is described, to assist in producing a systematic review that addresses if Obesity with orwithout metabolic syndrome alters intestine barrier function.
Herbal formula LLKL ameliorates hyperglycaemia, modulates the gut microbiota and regulates the gut‐liver axis in Zucker diabetic fatty rats
TLDR
It is demonstrated that LLKL ameliorates hyperglycaemia, modulates the gut microbiota and regulates the gut‐liver axis, which might contribute to its anti‐diabetic effect.
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