Gut pain and hyperalgesia induced by capsaicin: a human experimental model.

@article{Drewes2003GutPA,
  title={Gut pain and hyperalgesia induced by capsaicin: a human experimental model.},
  author={Asbj\orn Mohr Drewes and Klaus Peter Schipper and Georg Dimcevski and Poul Petersen and Hans Gregersen and Peter M Funch-Jensen and Lars Arendt-Nielsen},
  journal={Pain},
  year={2003},
  volume={104 1-2},
  pages={333-41}
}
Human experimental visceral pain models using chemical stimulation are needed for the study of visceral hyperexcitability. Our aim was to stimulate the human gut with chemical activators (capsaicin, glycerol) and measure quantitatively the induced hyperexcitability to painful mechanical gut distension. Ten otherwise healthy subjects with an ileostoma participated. Increasing volumes of capsaicin 50 microg/ml (0.25, 0.5, 0.75, 1.0, 1.5, 2.0, and 3 ml), glycerol (2.5, 5, and 10 ml) or saline (2.5… CONTINUE READING

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