Gut origin of sepsis: a prospective study investigating associations between bacterial translocation, gastric microflora, and septic morbidity.

@article{Macfie1999GutOO,
  title={Gut origin of sepsis: a prospective study investigating associations between bacterial translocation, gastric microflora, and septic morbidity.},
  author={John Macfie and C J O'Boyle and Charles J Mitchell and Paul M. Buckley and Duncan Johnstone and P Sudworth},
  journal={Gut},
  year={1999},
  volume={45 2},
  pages={
          223-8
        }
}
AIMS To investigate the "gut origin of sepsis" hypothesis. METHODS Prospective controlled study of 279 surgical patients in which cultures of nasogastric aspirates were compared with those obtained from mesenteric lymph nodes taken at laparotomy and the organisms cultured from subsequent septic complications. Bacterial translocation was confirmed if positive cultures were obtained from mesenteric lymph nodes. Postoperative sepsis was defined as any positive culture in the postoperative period… CONTINUE READING
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