Gut-on-a-Chip microenvironment induces human intestinal cells to undergo villus differentiation.

  title={Gut-on-a-Chip microenvironment induces human intestinal cells to undergo villus differentiation.},
  author={Hyun Jung Kim and Donald E. Ingber},
  journal={Integrative biology : quantitative biosciences from nano to macro},
  volume={5 9},
  • H. KimD. Ingber
  • Published 19 August 2013
  • Biology
  • Integrative biology : quantitative biosciences from nano to macro
Existing in vitro models of human intestinal function commonly rely on use of established epithelial cell lines, such as Caco-2 cells, which form polarized epithelial monolayers but fail to mimic more complex intestinal functions that are required for drug development and disease research. [] Key Result The cells of that line these villus structures are linked by tight junctions, and covered by brush borders and mucus.

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