Gut microbiota profiles and fecal beta‐glucuronidase activity in kidney transplant recipients with and without post‐transplant diarrhea

@article{Zhang2021GutMP,
  title={Gut microbiota profiles and fecal beta‐glucuronidase activity in kidney transplant recipients with and without post‐transplant diarrhea},
  author={Lisa T. Zhang and Lars F Westblade and Fatima Iqbal and Michael R. Taylor and Alice Chung and Michael J. Satlin and Matthew Magruder and Emmanuel Edusei and Shady Albakry and Brittany Botticelli and Amy E. Robertson and Tricia Alston and Darshana M. Dadhania and Michelle Lubetzky and Simon A. Hirota and Steven C. Greenway and John Richard Lee},
  journal={Clinical Transplantation},
  year={2021},
  volume={35}
}
Post‐transplant diarrhea is a common complication after solid organ transplantation and is frequently attributed to the widely prescribed immunosuppressant mycophenolate mofetil (MMF). Given recent work identifying the relationship between MMF toxicity and gut bacterial β‐glucuronidase activity, we evaluated the relationship between gut microbiota composition, fecal β‐glucuronidase activity, and post‐transplant diarrhea. We recruited 97 kidney transplant recipients and profiled the gut… 

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Evaluated the safety and efficacy of MMF 1.5 g every 12 h (q12) versus 1 g q12 [low‐dose, LD] and explored the association between neutropenia and GUS to explore the impact of gut bacteria β‐d‐glucuronidases on MMF bioavailability.

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Among the stream of synthesized compounds, 12e and 12i were the most potent inhibitors of β-glucuronidase, while 12h, 12i, and 12j showed greater potency against hCA II.

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