Gut microbiota modulation with norfloxacin and ampicillin enhances glucose tolerance in mice

  title={Gut microbiota modulation with norfloxacin and ampicillin enhances glucose tolerance in mice},
  author={M. Membrez and Florence Blancher and M. Jaquet and R. Bibiloni and Patrice D Cani and R. Burcelin and Ir{\`e}ne Corthesy and K. Mac{\'e} and C. Chou},
  journal={The FASEB Journal},
  pages={2416 - 2426}
  • M. Membrez, Florence Blancher, +6 authors C. Chou
  • Published 2008
  • Medicine, Biology
  • The FASEB Journal
  • Recent data suggest that the gut microbiota plays a significant role in fat accumulation. However, it is not clear whether gut microbiota is involved in the pathophysiology of type 2 diabetes. To assess this issue, we modulated gut microbiota via antibiotics administration in two different mouse models with insulin resistance. Results from dose‐determination studies showed that a combination of norfloxacin and ampicillin, at a dose of 1g/L, maximally suppressed the numbers of cecal aerobic and… CONTINUE READING
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    • Zakład Regulacji Metabolizmu, Instytut Biochemii, Wydział Biologii
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