Gut microbiota-mediated drug interactions between lovastatin and antibiotics.

Abstract

Orally administered drugs may be metabolized by intestinal microbial enzymes before absorption into the blood. Accordingly, coadministration of drugs affecting the metabolic activities of gut microbes (e.g., antibiotics) may lead to drug-drug interactions (DDI). In this study, gut microbiota-mediated DDI were investigated by studying the pharmacokinetics of… (More)
DOI: 10.1124/dmd.114.058354

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