Gut microbiota in health and disease.

@article{Sekirov2010GutMI,
  title={Gut microbiota in health and disease.},
  author={I. Sekirov and S. Russell and L. Antunes and B. Finlay},
  journal={Physiological reviews},
  year={2010},
  volume={90 3},
  pages={
          859-904
        }
}
Gut microbiota is an assortment of microorganisms inhabiting the length and width of the mammalian gastrointestinal tract. The composition of this microbial community is host specific, evolving throughout an individual's lifetime and susceptible to both exogenous and endogenous modifications. Recent renewed interest in the structure and function of this "organ" has illuminated its central position in health and disease. The microbiota is intimately involved in numerous aspects of normal host… Expand

Paper Mentions

Interventional Clinical Trial
The objective of this study is to assess the feasibility of a novel colonic and oral fecal microbiota transplantation protocol for the treatment of active pediatric Crohn's disease… Expand
ConditionsColitis, Crohn Disease, Inflammatory Bowel Diseases, (+1 more)
InterventionBiological
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References

SHOWING 1-10 OF 397 REFERENCES
Interactions of the Intestinal Epithelium with the Pathogen and the Indigenous Microbiota: A Three-Way Crosstalk
TLDR
Although it is only the beginning, it promises to be an exciting era in the study of these host-microbe relationships, including the synthesis of nutrients, protection against infection, and the development of the immune system. Expand
The role of the intestinal microbiota in enteric infection
TLDR
Uncovering the mechanisms underlying the host–pathogen‐microbiota interactions will facilitate the understanding of the infection process and promote design of more effective and focused prophylactic and therapeutic strategies. Expand
Microbes in gastrointestinal health and disease.
  • A. Neish
  • Biology, Medicine
  • Gastroenterology
  • 2009
TLDR
Gaining a fuller understanding of both partners in the normal gut-microbiota interaction may shed light on how the relationship can go awry and contribute to a spectrum of immune, inflammatory, and metabolic disorders and may reveal mechanisms by which this relationship could be manipulated toward therapeutic ends. Expand
Intestinal colonization, microbiota, and probiotics
TLDR
Genomic information and improved knowledge of microbiotic composition and its aberrancies should serve as a basis for selecting new probiotics for use in specific infant populations, followed by lactic acid bacteria, which favor specific healthy bifidobacterial growth and species composition. Expand
The relationship between intestinal microbiota and the central nervous system in normal gastrointestinal function and disease.
TLDR
Gaining a better understanding of the relationship between behavior and the microbiota could provide insight into the pathogenesis of functional and inflammatory bowel disorders. Expand
Paneth cells, defensins, and the commensal microbiota: a hypothesis on intimate interplay at the intestinal mucosa.
TLDR
Future studies to further define mechanisms by which defensins and other host factors regulate the composition of the intestinal microbiota will likely provide new insights into intestinal homeostasis and new therapeutic strategies for inflammatory and infectious diseases of the bowel. Expand
Predominant Role of Host Genetics in Controlling the Composition of Gut Microbiota
TLDR
This is the first report that clearly establishes the link between the host genotype and the corresponding shifts in the gut microbiota, which suggests that the host genetics is a key factor in host-microbe interaction determining a specific profile of commensal microbiota in the human gut. Expand
Nutrition and colonic health: the critical role of the microbiota
  • S. O'keefe
  • Biology, Medicine
  • Current opinion in gastroenterology
  • 2008
TLDR
Investigations have focused on a small number of bacterial species: characterization of microbiota and its metabolism can be expected to provide the key to colonic health and disease. Expand
The role of microbiota and probiotics in stress-induced gastro-intestinal damage.
TLDR
Based on the studies reviewed here, there is clearly a rationale for probiotic treatment in patients with stress-related intestinal disorders and the possibilities to counteract the deleterious effects of stress with probiotics. Expand
Effects of gut microbiota on the brain: implications for psychiatry.
TLDR
This commentary provides a brief overview of research related to gut‐brain communication in a context that allows neuroscientists and psychiatrists to take note and consider the role of microbiota in their researchrelated to CNS function and behaviour. Expand
...
1
2
3
4
5
...