Gut microbiome remodeling induces depressive-like behaviors through a pathway mediated by the host’s metabolism

@article{Zheng2016GutMR,
  title={Gut microbiome remodeling induces depressive-like behaviors through a pathway mediated by the host’s metabolism},
  author={Peng Zheng and Benhua Zeng and C Zhou and Mingbo Liu and Zhichao Fang and Xiaojuan Xu and Li Zeng and Jianhuan Chen and S Fan and Xiang-yu Du and Xingdong Zhang and De-Yu Yang and Yingying Yang and Haiying Meng and Wenxin Li and Narayan Dhruvaraj Melgiri and Julio Licinio and Hua Wei and Peng Xie},
  journal={Molecular Psychiatry},
  year={2016},
  volume={21},
  pages={786-796}
}
Major depressive disorder (MDD) is the result of complex gene–environment interactions. According to the World Health Organization, MDD is the leading cause of disability worldwide, and it is a major contributor to the overall global burden of disease. However, the definitive environmental mechanisms underlying the pathophysiology of MDD remain elusive. The gut microbiome is an increasingly recognized environmental factor that can shape the brain through the microbiota-gut-brain axis. We show… CONTINUE READING
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