Gut microbiome composition and function in experimental colitis during active disease and treatment-induced remission

@article{Rooks2014GutMC,
  title={Gut microbiome composition and function in experimental colitis during active disease and treatment-induced remission},
  author={Michelle G. Rooks and Patrick Veiga and Leslie H Wardwell-Scott and Timothy L. Tickle and Nicola Segata and Monia Michaud and Carey Ann Gallini and Chlo{\'e} B{\'e}al and Johan ET van Hylckama-Vlieg and Sonia Arora Ballal and Xochitl C. Morgan and Jonathan N Glickman and Dirk Gevers and Curtis Huttenhower and Wendy S. Garrett},
  journal={The ISME Journal},
  year={2014},
  volume={8},
  pages={1403-1417}
}
Dysregulated immune responses to gut microbes are central to inflammatory bowel disease (IBD), and gut microbial activity can fuel chronic inflammation. Examining how IBD-directed therapies influence gut microbiomes may identify microbial community features integral to mitigating disease and maintaining health. However, IBD patients often receive multiple treatments during disease flares, confounding such analyses. Preclinical models of IBD with well-defined disease courses and opportunities… CONTINUE READING

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