Gut microbial products regulate murine gastrointestinal motility via Toll-like receptor 4 signaling.

@article{Anitha2012GutMP,
  title={Gut microbial products regulate murine gastrointestinal motility via Toll-like receptor 4 signaling.},
  author={Mallappa Anitha and Matam Vijay-Kumar and Shanthi V. Sitaraman and Andrew T. Gewirtz and S. Deepak Srinivasan},
  journal={Gastroenterology},
  year={2012},
  volume={143 4},
  pages={1006-16.e4}
}
BACKGROUND & AIMS Altered gastrointestinal motility is associated with significant morbidity and health care costs. Toll-like receptors (TLR) regulate intestinal homeostasis. We examined the roles of TLR4 signaling in survival of enteric neurons and gastrointestinal motility. METHODS We assessed changes in intestinal motility by assessing stool frequency, bead expulsion, and isometric muscle recordings of colonic longitudinal muscle strips from mice that do not express TLR4 (Tlr4(Lps-d) or… CONTINUE READING
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