Gut hormones and the regulation of energy homeostasis

@article{Murphy2006GutHA,
  title={Gut hormones and the regulation of energy homeostasis},
  author={Kevin G Murphy and Stephen Robert Bloom},
  journal={Nature},
  year={2006},
  volume={444},
  pages={854-859}
}
Food intake, energy expenditure and body adiposity are homeostatically regulated. Central and peripheral signals communicate information about the current state of energy balance to key brain regions, including the hypothalamus and brainstem. Hunger and satiety represent coordinated responses to these signals, which include neural and hormonal messages from the gut. In recent years our understanding of how neural and hormonal brain–gut signalling regulates energy homeostasis has advanced… Expand
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  • 2010
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References

SHOWING 1-10 OF 111 REFERENCES
The Gut and Energy Balance: Visceral Allies in the Obesity Wars
TLDR
In addition to digesting and assimilating nutrients, the intestine and associated visceral organs play a key sensing and signaling role in the physiology of energy homeostasis and have led to exploration of novel routes for obesity control, some of which involve gut-derived pathways. Expand
Ghrelin action in the brain controls adipocyte metabolism.
TLDR
The existence of what is believed to be a new CNS-based neuroendocrine circuit regulating metabolic homeostasis of adipose tissue is unraveled by examining central action of the orexigenic hormone ghrelin. Expand
Central nervous system control of food intake
TLDR
A model is described that delineates the roles of individual hormonal and neuropeptide signalling pathways in the control of food intake and the means by which obesity can arise from inherited or acquired defects in their function. Expand
Effects of obestatin on energy balance and growth hormone secretion in rodents.
TLDR
The results presented here do not support a role of the obestatin/GPR-39 system in the regulation of energy balance, and it is concluded that ghrelin stimulates food intake and adiposity and thereby increases body weight in rodents after central as well as peripheral administration. Expand
Ghrelin induces adiposity in rodents
TLDR
It is proposed that ghrelin, in addition to its role in regulating GH secretion, signals the hypothalamus when an increase in metabolic efficiency is necessary, suggesting an involvement in regulation of energy balance. Expand
Anatomy and regulation of the central melanocortin system
  • R. Cone
  • Biology, Medicine
  • Nature Neuroscience
  • 2005
TLDR
Given that the central melanocortin system is an active target for development of drugs for the treatment of obesity, diabetes and cachexia, it is important to understand the system in its full complexity, including the likelihood that the system also regulates the cardiovascular and reproductive systems. Expand
Ghrelin and the short- and long-term regulation of appetite and body weight
TLDR
Extant evidence favors roles for ghrelin in both short-term meal initiation and long-term energy homeostasis, making it an attractive target for drugs to treat obesity and/or wasting disorders. Expand
Critical role for peptide YY in protein-mediated satiation and body-weight regulation.
TLDR
It is suggested that modulating the release of endogenous satiety factors, such as PYY, through alteration of specific diet constituents could provide a rational therapy for obesity. Expand
Characterization of the effects of pancreatic polypeptide in the regulation of energy balance.
TLDR
Observations indicate that PP may influence food intake, energy metabolism, and the expression of hypothalamic peptides and gastric ghrelin. Expand
Pancreatic polypeptide reduces appetite and food intake in humans.
TLDR
The data demonstrates that PP causes a sustained decrease in both appetite and food intake, which suggests that PP may act as a circulating factor that regulates food intake. Expand
...
1
2
3
4
5
...