Gut homing receptors on CD8 T cells are retinoic acid dependent and not maintained by liver dendritic or stellate cells.

@article{Eksteen2009GutHR,
  title={Gut homing receptors on CD8 T cells are retinoic acid dependent and not maintained by liver dendritic or stellate cells.},
  author={Bertus Eksteen and J Rodrigo Mora and Emma L Haughton and Neil C. Henderson and Laura Lee-Turner and Eduardo J Villablanca and Stuart M. Curbishley and Alex I. Aspinall and Ulrich H von Andrian and David H Adams},
  journal={Gastroenterology},
  year={2009},
  volume={137 1},
  pages={320-9}
}
BACKGROUND & AIMS Lymphocytes primed by intestinal dendritic cells (DC) express the gut-homing receptors CCR9 and alpha4beta7, which recognize CCL25 and mucosal addressin cell-adhesion molecule-1 in the intestine promoting the development of regional immunity. In mice, imprinting of CCR9 and alpha4beta7 is dependent on retinoic acid during T-cell activation… CONTINUE READING